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Prefrontal cortical circuits in anxiety and fear: an overview

《医学前沿(英文)》 2022年 第16卷 第4期   页码 518-539 doi: 10.1007/s11684-022-0941-2

摘要: Pathological anxiety is among the most difficult neuropsychiatric diseases to treat pharmacologically, and it represents a major societal problem. Studies have implicated structural changes within the prefrontal cortex (PFC) and functional changes in the communication of the PFC with distal brain structures in anxiety disorders. Treatments that affect the activity of the PFC, including cognitive therapies and transcranial magnetic stimulation, reverse anxiety- and fear-associated circuit abnormalities through mechanisms that remain largely unclear. While the subjective experience of a rodent cannot be precisely determined, rodent models hold great promise in dissecting well-conserved circuits. Newly developed genetic and viral tools and optogenetic and chemogenetic techniques have revealed the intricacies of neural circuits underlying anxiety and fear by allowing direct examination of hypotheses drawn from existing psychological concepts. This review focuses on studies that have used these circuit-based approaches to gain a more detailed, more comprehensive, and more integrated view on how the PFC governs anxiety and fear and orchestrates adaptive defensive behaviors to hopefully provide a roadmap for the future development of therapies for pathological anxiety.

关键词: prefrontal cortex     anxiety     fear     neural circuits     optogenetics     DREADD    

Measuring residents’ anxiety under urban redevelopment in China: An investigation of demographic variables

Jinbo SONG, Chen QIAN, Zhuo FENG, Liang MA

《工程管理前沿(英文)》 2021年 第8卷 第1期   页码 48-59 doi: 10.1007/s42524-020-0131-3

摘要: Residents’ concerns and feelings play pivotal roles in smoothly promoting urban redevelopment. Anxiety, as an intuitive feeling toward uncertainties, generally exists among residents who are confronted with redevelopment, and this feeling has gradually attracted scholars’ attention. However, relatively few studies have focused on the multidimensional view of this concept and its influencing factors. Drawing upon a large-scale questionnaire survey conducted in 13 pilot areas in China, this study refines and verifies five prominent dimensions of anxiety, namely, housing conditions, monetary compensation, public services, life adaptation, and public participation level, through factor analysis and one-sample -test. The finding contributes to achieving a complete understanding of anxiety, and the scales developed for measuring these dimensions lay the foundation for further empirical studies on anxiety. The individual and collective effects of age, job, and region variables on anxiety dimensions are demonstrated via independent-sample -test and analysis of variance, which clarifies the formation process of anxiety and highlights the importance of these contextual variables. Tailored strategies for policymaking and engineering management, including establishing reasonable compensation standards, providing equal public services, and delivering high-quality housing, are proposed to relieve residents’ anxiety. These strategies are expected to consider further the sensitive group, such as the elderly, farmers, and casual workers.

关键词: urban redevelopment     anxiety dimension     influencing factors     ANOVA     policymaking    

标题 作者 时间 类型 操作

Prefrontal cortical circuits in anxiety and fear: an overview

期刊论文

Measuring residents’ anxiety under urban redevelopment in China: An investigation of demographic variables

Jinbo SONG, Chen QIAN, Zhuo FENG, Liang MA

期刊论文